Our general aim is to systematically collect Anopheles gambiae samples across the different ecological areas of Ethiopia and to analyze the dynamics of genes associated with insecticides resistance, determine genetic diversity and population structure and to explore the frequency of the 2La chromosomal inversion in an An. gambiae (s.s.) population in Ethiopia.

Objectives:

• To determine the prevalence of mutations conferring resistance to DDT and pyrethroids (Kdr 1014F or 1014S)
• To determine the frequency of G119S mutation conferring resistance organophosphates (OPs) and carbamates (CMs)
• To determine the frequency of metabolic resistance involved in insecticide degradation in detoxification genes such carboxylesterases (CoEs), cytochrome P450 mono-oxygenases (P450s) and glutathione S-transferases (GSTs)
• To determine the frequency of 2La chromosomal inversion.
• To determine the genetic diversity (CYP6P9a) and population structure of An. gambiae in different regions of Ethiopia

Contributors:

• Lemu Golassa: Akililu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
• Sisay Dugassa: Akililu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
• Deriba Abera: Department of Medical Laboratory Sciences and Pathology, Jimma University, Jimma, Oromia, Ethiopia