Partner study description

Samples from Papua New Guinea were collected as part of ongoing malaria surveillance efforts to build a national repository of malaria isolates. Some of these samples were obtained as part of MalariaGEN Consortial Project 1. These samples helped form the cornerstone of MalariaGEN’s initial efforts to characterise Plasmodium genome variation, and contributed to the development of field and lab-based sample handling methods, sequencing approaches, and data analysis pipelines. In a follow-up study, MalariaGEN is working with Dr Alyssa Barry from the Walter and Eliza Hall Institute, Australia, to sequence Plasmodium falciparum isolates from two additional populations and to develop a PNG-specific assay for genotyping and population genetic studies of a nation-wide P. falciparum sample collection.

Publications

• Genomic epidemiology of artemisinin resistant malaria
  MalariaGEN P. falciparum Community Project
  eLife, 2016; 5 e08714
  10.7554/eLife.08714
• Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
  Manske et al.
  Nature, 2012; 487(7407) 375-9
  10.1038/nature11174
• Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay
  Campino S et al.
  PLoS One, 2011; 6(6) e20251
  10.1371/journal.pone.0020251