Partner study description

Samples were collected in the southern province of Binh Phuoc, Vietnam, as part of a set of clinical studies initiated by Professor Tran Tinh Hien and Christiane Dolecek in 2009 to measure in vivo and in vitro drug sensitivity in this region. In collaboration with Maciej Boni, Professor Hien’s research team also worked towards characterising signatures of sulfadoxine/pyrimethamine and chloroquine resistance, and pfMDR copy number in these samples using the Illumina sequence and genotype data.

Where samples were found to contain Plasmodium vivax data, for example due to mixed infection, this data was contributed to the P. vivax Genome Variation project.

Publications

• Genomic analysis of local variation and recent evolution in Plasmodium vivax
  Pearson et al
  Nature Genetics, 2016; 48 959-964
  10.1038/ng.3599
• Genomic epidemiology of artemisinin resistant malaria
  MalariaGEN P. falciparum Community Project
  eLife, 2016; 5 e08714
  10.7554/eLife.08714
• Genetic architecture of artemisinin-resistant Plasmodium falciparum
  Miotto et al
  Nature Genetics, 2015; 47(3) 226-34
  10.1038/ng.3189
• Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
  Miotto et al
  Nature Genetics, 2013; 45(6) 648-55
  10.1038/ng.2624
• Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay
  Campino S et al.
  PLoS One, 2011; 6(6) e20251
  10.1371/journal.pone.0020251