Partner study description

Xin-zhuan Su and colleagues provided samples from their field site in Pursat province, Cambodia at an early stage in the MalariaGEN P. falciparum Community Project. These samples were contributed to support the development of our sequencing and analysis pipelines, and to provide geographical representation of parasites from Cambodia for preliminary analysis of global population structure. For the analyses, the parasites were culture adapted and analysed for genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs.

Publications

• Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study
  Amato, Lim, et al.
  The Lancet Infectious Diseases, 2016;
  10.1016/S1473-3099(16)30409-1
• Genomic epidemiology of artemisinin resistant malaria
  MalariaGEN P. falciparum Community Project
  eLife, 2016; 5 e08714
  10.7554/eLife.08714
• Genetic architecture of artemisinin-resistant Plasmodium falciparum
  Miotto et al
  Nature Genetics, 2015; 47(3) 226-34
  10.1038/ng.3189
• Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
  Miotto et al
  Nature Genetics, 2013; 45(6) 648-55
  10.1038/ng.2624
• Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
  Manske et al.
  Nature, 2012; 487(7407) 375-9
  10.1038/nature11174
• Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay
  Campino S et al.
  PLoS One, 2011; 6(6) e20251
  10.1371/journal.pone.0020251