Partner study description

ARCE is a WHO-lead strategy for the containment of artemisinin resistant parasites in Southeast Asia, aiming to ultimately contribute to the elimination of falciparum malaria from the area. Samples collected as part of ARCE-lead studies of artesunate efficacy at sites in Myanmar, Laos and Viet Nam were contributed to the MalariaGEN P. falciparum Community Project for whole genome sequencing and subsequent analysis of genetic variation, population structure and signatures of selection. The genetic data is also being used in a replication genome-wide association study to validate and extend the outcomes of the ARC3 GWAS, with the hope of identifying molecular markers of artemisinin resistance.

Publications

• Genomic epidemiology of artemisinin resistant malaria
  MalariaGEN P. falciparum Community Project
  eLife, 2016; 5 e08714
  10.7554/eLife.08714
• Genetic architecture of artemisinin-resistant Plasmodium falciparum
  Miotto et al
  Nature Genetics, 2015; 47(3) 226-34
  10.1038/ng.3189