Partner study description

In Burkina Faso, Jean-Bosco Ouedraogo and his colleagues worked with the MalariaGEN team to collect samples from three urban clinics in Bobo-Dioulasso – Colsama, Ouezzin-ville and Sakaby – each up to 8km from the laboratory at the Institut de Recherche en Sciences de la Santé. These samples helped form the cornerstone of MalariaGEN’s initial efforts to characterise global Plasmodium genome variation, and contributed to the development of field and lab-based sample handling methods, sequencing approaches, and data analysis pipelines. Jean-Bosco and team are keen to investigate signatures of population structure and other unique features of genome variation between the three locations where samples were collected.

Publications

• Genomic epidemiology of artemisinin resistant malaria
  MalariaGEN P. falciparum Community Project
  eLife, 2016; 5 e08714
  10.7554/eLife.08714
• Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
  Miotto et al
  Nature Genetics, 2013; 45(6) 648-55
  10.1038/ng.2624
• Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
  Manske et al.
  Nature, 2012; 487(7407) 375-9
  10.1038/nature11174
• Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data
  Auburn et al
  PLoS One, 2012; 7(2) e32891
  10.1371/journal.pone.0032891
• An effective method to purify Plasmodium falciparum DNA directly from clinical blood samples for whole genome high-throughput sequencing
  Auburn et al.
  PLoS One, 2011; 6(7) e22213
  10.1371/journal.pone.0022213
• Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay
  Campino S et al.
  PLoS One, 2011; 6(6) e20251
  10.1371/journal.pone.0020251