The Plasmodium parasites that cause malaria have a remarkable talent for survival. Through small genetic changes, they can evade the human immune system, develop resistance to antimalarial drugs, and adapt to changes in the Anopheles mosquitoes that transmit the parasites.
The MalariaGEN open Plasmodium genetic data resource is the world’s largest data set of curated whole genome sequence data on malaria parasites. Through open data and applications that enable users to analyse and compute data free of charge, this resource provides the reference data needed in the search for new genetic insights on the spread and evolution of Plasmodium parasites to guide malaria control interventions.
We’re building genomic data and tools for investigating genetic variation in Plasmodium parasites that cause malaria to answer crucial questions about malaria transmission and drug resistance.
Data
Whole genome data releases of malaria parasite samples from across the globe, including sample metadata and single nucleotide polymorphism (SNP) calls.
Pf7
An open dataset of Plasmodium falciparum genome variation in 20,000+ worldwide samplesPv4
An open dataset of Plasmodium vivax genome variation dataTo access the data on the cloud, view terms of use, and browse guides to run your analyses, see the MalariaGEN parasite data user guide.
These analysis-ready genomic data resources on malaria parasites have been made freely available to everyone to benefit malaria research and public health, subject to access approval and terms of use. Alternatively, data can be downloaded to your own compute resources to run analyses locally.
Training
Learn how to access, visualise, and recreate analyses of Plasmodium data for free with our guided analysis notebooks and the MalariaGEN data Python package.
Apps
Use our free apps to analyse parasite genomic data and discover new insights.
Pf7
An open dataset of P. falciparum genome variation in 20,000+ worldwide samples. View data from nearly 100 locations across 30+ countries, summaries of genetic markers of drug resistance, and more.Pf-HaploAtlas
The Plasmodium falciparum Haplotype Atlas allows anyone with an internet connection to study and track genetic variation in any gene in the P. falciparum genome.Collaborations
MalariaGEN data resources are built through the collaborative efforts of individuals, groups, and institutions around the world. The Plasmodium resource lists each sample against the partner study that it belongs to, with a description of the scientific aims of the study and the local investigators that led the work.
P. falciparum Community Project
Provides high-quality genotypes linked to a global resource characterising genetic variation in P. falciparum populations.P. vivax Genome Variation
Aims to understand genome diversity of P. vivax parasites that can remain dormant in the liver for years, making them particularly hard to eliminate using conventional measures.P. falciparum Genetic Crosses
Generating high-quality data on genome sequence variation and sexual recombination for the parents and progeny of parasite crosses.Pf3k
An international collaboration using the latest sequencing technologies to provide a high-resolution view of natural variation in P. falciparum parasites.GenRe-Mekong (Genetic Reconnaissance of Malaria in the Greater Mekong Subregion)
Providing National Malaria Control Programmes and other public health stakeholders in the Greater Mekong Subregion with timely and actionable knowledge to support decision-making relevant to malaria elimination efforts.Genomic Surveillance Hubs in West Africa (NIHR Global Health Research Group)
Establishing the scientific, technical, and operational infrastructure for regional genomic surveillance hubs in The Gambia and Ghana where P. falciparum samples from countries across the region can be collected, sequenced, and analysed locally.Pan-African Malaria Genetic Epidemiology Network (PAMGEN)
PAMGEN is researching genetic interactions between malaria parasites, vectors, and human communities across different African environments using the latest genomics science to contribute towards malaria elimination efforts in Africa.SpotMalaria
SpotMalaria harnesses genomic technologies to monitor the global evolution of malaria parasites, delivering knowledge that will increase the efficiency of malaria elimination and eradication efforts.
Research
MalariaGEN data resources are powering new research into the genomic epidemiology of malaria parasites.
Characterisation of the erythrocyte invasion phenotype of FCB-2: A South American P. falciparum reference strain
Monica Ararat-Sarria, Hernando Curtidor and Manuel Alfonso Patarroyo
Acta Tropica 2024;260;107379
ResMAP—a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium
Richard J. Wall, Stuart A. MacGowan, Irene Hallyburton, Aisha J. Syed, Sowmya Ajay Castro, Gourav Dey, Rachel Milne, Stephen Patterson, Jody Phelan, Natalie Wiedemar, Susan Wyllie
mBio 2024;e0170824
Detection of novel Plasmodium falciparum haplotypes under treatment pressure in pediatric severe malaria
Balotin Fogang, Emilie Guillochon, Claire Kamaliddin, Gino Agbota, Sem Ezinmegnon, Maroufou Jules Alao, Philippe Deloron, Gwladys Bertin, Antoine Claessens
medRxiv 2024
Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia
Marc-Antoine Guery, Sukai Ceesay, Sainabou Drammeh, Fatou K Jaiteh, Umberto d’Alessandro, Teun Bousema, David J Conway, Antoine Claessens
medRxiv 2024
Diversity and selection analyses identify transmission-blocking antigens as the optimal vaccine candidates in Plasmodium falciparum
Ilinca I Ciubotariu, Bradley K Broyles, Shaojun Xie, Jyothi Thimmapuram, Mulenga C Mwenda, Brenda Mambwe, Conceptor Mulube, Japhet Matoba, Jessica L Schue, William J Moss, Daniel J Bridges, Qixin He, Giovanna Carpi
eBioMedicine 2024;106;105227
Benchmarking and Optimization of Methods for the Detection of Identity-By-Descent in High-Recombining Plasmodium falciparum Genomes
Bing Guo, Shannon Takala-Harrison, Timothy D. O’Connor
bioRxiv 2024
Ancient Plasmodium genomes shed light on the history of human malaria
Megan Michel, Eirini Skourtanioti, Federica Pierini, Evelyn K. Guevara, Angela Mötsch, Arthur Kocher, Rodrigo Barquera, Raffaela A. Bianco, Selina Carlhoff, Lorenza Coppola Bove, Suzanne Freilich, Karen Giffin, Taylor Hermes, Alina Hiß, Florian Knolle, Elizabeth A. Nelson, Gunnar U. Neumann, Luka Papac, Sandra Penske, Adam B. Rohrlach, Nada Salem, Lena Semerau, Vanessa Villalba-Mouco, Isabelle Abadie, Mark Aldenderfer, Jessica F. Beckett, Matthew Brown, Franco G. R. Campus, Tsang Chenghwa, María Cruz Berrocal, Ladislav Damašek, Kellie Sara Duffett Carlson, Raphaël Durand, Michal Ernée, Cristinel Fântăneanu, Hannah Frenzel, Gabriel García Atiénzar, Sonia Guillén, Ellen Hsieh, Maciej Karwowski, David Kelvin, Nikki Kelvin, Alexander Khokhlov, Rebecca L. Kinaston, Arkadii Korolev, Kim-Louise Krettek, Mario Küßner, Luca Lai, Cory Look, Kerttu Majander, Kirsten Mandl, Vittorio Mazzarello, Michael McCormick, Patxuka de Miguel Ibáñez, Reg Murphy, Rita E. Németh, Kerkko Nordqvist, Friederike Novotny, Martin Obenaus, Lauro Olmo-Enciso, Päivi Onkamo, Jörg Orschiedt, Valerii Patrushev, Sanni Peltola, Alejandro Romero, Salvatore Rubino, Antti Sajantila, Domingo C. Salazar-García, Elena Serrano, Shapulat Shaydullaev, Emanuela Sias, Mario Šlaus, Ladislav Stančo, Treena Swanston, Maria Teschler-Nicola, Frederique Valentin, Katrien Van de Vijver, Tamara L. Varney, Alfonso Vigil-Escalera Guirado, Christopher K. Waters, Estella Weiss-Krejci, Eduard Winter, Thiseas C. Lamnidis, Kay Prüfer, Kathrin Nägele, Maria Spyrou, Stephan Schiffels, Philipp W. Stockhammer, Wolfgang Haak, Cosimo Posth, Christina Warinner, Kirsten I. Bos, Alexander Herbig & Johannes Krause
Nature 2024;631;125–133
Genetic surveillance of Plasmodium falciparum reveals rapid population changes following first-line treatment policy revisions in the Greater Mekong Subregion
Tess D Verschuuren, Varanya Wasakul, Nguyen Thuy-Nhien, Ethan Booth, Huynh Hong Quang, Ngo Duc Thang, Keobouphaphone Chindavongsa, Siv Sovannaroth, Virasak Banouvong, Viengphone Sengsavath, Mayfong Mayxay, Nguyen Thi Kim Tuyen, Vo Ngoc Lam Phuong, Pham Duc Trung, Sónia Gonçalves, Soun Chen, Sonexay Phalivong, Saiamphone Xayvanghang, Supaporn Mahaphontrakoon, Richard D Pearson, Paul N Newton, Richard J Maude, Elizabeth A Ashley, Cristina V Ariani, Victoria J Simpson, Nicholas P Day, Arjen M Dondorp, Olivo Miotto
medRxiv 2024
Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar
Aung Myint Thu, Aung Pyae Phyo, Chanapat Pateekhum, Jade D. Rae, Jordi Landier, Daniel M. Parker, Gilles Delmas, Wanitda Watthanaworawit, Alistair R. D. McLean, Ann Arya, Ann Reyes, Xue Li, Olivo Miotto, Kyaw Soe, Elizabeth A. Ashley, Arjen Dondorp, Nicholas J. White, Nicholas P. Day, Tim J. C. Anderson, Mallika Imwong, Francois Nosten & Frank Smithuis
Malaria Journal 2024;23(138)
Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity
Beatus M. Lyimo, Catherine Bakari, Zachary R. Popkin-Hall, David J. Giesbrecht, Misago D. Seth, Dativa Pereus, Zulfa I. Shabani, Ramadhan Moshi, Ruth Boniface, Celine I. Mandara, Rashid Madebe, Jonathan J. Juliano, Jeffrey A. Bailey & Deus S. Ishengoma
Malaria Journal 2024;23(1);139
Sustained clinical benefit of malaria chemoprevention with sulfadoxine-pyrimethamine (SP) in pregnant women in a region with high SP resistance markers
Glória Matambisso, Nanna Brokhattingen, Sónia Maculuve, Pau Cístero, Henriques Mbeve, Anna Escoda, Gizela Bambo, Boaventura Cuna, Cardoso Melembe, Nelo Ndimande, Kevin K.A. Tetteh, Chris Drakeley, Benoit Gamain, Chetan Chitnis, Virander Chauhan, Llorenç Quintó, Eusébio Macete, Alfredo Mayor
Journal of Infection 2024;88;(5)
Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum
Bing Guo, Victor Borda, Roland Laboulaye, Michele D. Spring, Mariusz Wojnarski, Brian A. Vesely, Joana C. Silva, Norman C. Waters, Timothy D. O’Connor & Shannon Takala-Harrison
Nat Commun 2024;15;2499
Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial
Kevin Wamae, Leonard Ndwiga, Oksana Kharabora, Kelvin Kimenyi, Victor Osoti, Zaydah de Laurent, Juliana Wambua, Jennifer Musyoki, Caroline Ngetsa, Peter Kalume, Gabriel Mwambingu, Mainga Hamaluba, Rob van der Pluijm, Arjen M Dondorp, Jeffrey Bailey, Jonathan Juliano, Philip Bejon, Lynette Ochola-Oyier
Wellcome Open Research 2024;7;95
scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria
Collins M. Morang’a, Riley S. Drake, Vincent N. Miao, Nancy K. Nyakoe, Dominic S.Y. Amuzu, Vincent Appiah, Yaw Aniweh, Yaw Bediako, Saikou Y. Bah, Alex K. Shalek, Gordon A. Awandare, Thomas D. Otto, Lucas Amenga–Etego
medRxiv 2024
Regional Plasmodium falciparum subpopulations and malaria transmission connectivity in Africa detected with an enlarged panel of genome-wide microsatellite loci.
Martha Anita Demba, Edwin Kamau, Jaishree Raman, Karim Mane, Lucas Emenga-Etego, Tobias Apinjo, Deus Isheghoma, Lemu Golassa, Oumou Maiga, Anita Ghansah, Marielle Bouyou-Akotet, William Yavo, Milijoana Randrianarivelojosia, Fadel Muhammadou Diop, Eniyou Oriero, David Jeffries, Umberto D’Alessandro, Abdoulaye Djimde, Alfred Amambua-Ngwa
bioRxiv 2024
Role for gene conversion in the evolution of cell-surface antigens of the malaria parasite Plasmodium falciparum
Brice Letcher, Sorina Maciuca, Zamin Iqbal
PLOS Biology 2024;22(3);e3002507
Evaluating evidence for co-geography in the Anopheles–Plasmodium host-parasite system
Clara T Rehmann, Peter L Ralph, Andrew D Kern
G3 Genes Genomes Genetics 2024; 14;(3)
Plasmodium falciparum transmission in the highlands of Ethiopia is driven by closely related and clonal parasites
Aurel Holzschuh, Yalemwork Ewnetu, Lise Carlier, Anita Lerch, Inna Gerlovina, Sarah Cate Baker, Delenasaw Yewhalaw, Werissaw Haileselassie, Nega Berhane, Wossenseged Lemma, Cristian Koepfli
Mol Ecol 2024;33(6);e17292
Artemisinin resistance-associated gene mutations in Plasmodium falciparum: A case study of severe malaria from Mozambique
Daniela Casanova, Vitória Baptista, Magda Costa, Bruno Freitas, Maria das Neves Imaculada Pereira, Carla Calçada, Paula Mota, Olena Kythrich, Maria Helena Jacinto Sarmento Pereira, Nuno S. Osório, Maria Isabel Veiga
Travel Medicine and Infectious Disease 2024;57;102684
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
Clare Andradi-Brown, Jan Stephan Wichers-Misterek, Heidrun von Thien, Yannick D Höppner, Judith AM Scholz, Helle Hansson, Emma Filtenborg Hocke, Tim Wolf Gilberger, Michael F Duffy, Thomas Lavstsen, Jake Baum, Thomas D Otto, Aubrey J Cunnington ,Anna Bachmann
eLife 2024;25;12:RP87726
The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites
Sabine Schmidt, Jan Stephan Wichers-Misterek, Hannah Michaela Behrens, Jakob Birnbaum, Isabelle G. Henshall, Jana Dröge, Ernst Jonscher, Sven Flemming, Carolina Castro-Peña, Paolo Mesén-Ramírez, Tobias Spielmann
PLoS Pathog 2023;19(12);e1011814
Genomic analysis of Plasmodium vivax describes patterns of connectivity and putative drivers of adaptation in Ethiopia
Alebachew Messele Kebede , Edwin Sutanto , HidayatTrimarsanto, Ernest Diez Benavente , Mariana Barnes, Richard D. Pearson, Sasha V. Siegel , Berhanu Erko, Ashenafi Assefa, Sisay Getachew, Abraham Aseffa , Beyene Petros, Eugenia Lo, Rezika Mohammed, Daniel Yilma, Angela Rumaseb , Francois Nosten, Rintis Noviyanti , Julian C. Rayner, Dominic P. Kwiatkowski, Ric N. Price, LemuGolassa & Sarah Auburn
Scientific Reports 2023;13;20788
Genomics of Plasmodium vivax in Colombia reveals evidence of local bottle-necking and inter-country connectivity in the Americas
Edwin Sutanto, Zuleima Pava, Diego F. Echeverry, Tatiana M. Lopera‑Mesa, Lidia Madeline Montenegro, Maria F.Yasnot‑Acosta, Ernest Diez Benavente, Richard D. Pearson, Sócrates Herrera, Myriam Arévalo‑Herrera, Hidayat Trimarsanto, Angela Rumaseb , Rintis Noviyanti, Dominic P. Kwiatkowski, Ric N. Price & Sarah Auburn
Scientific Reports 2023;13;19779
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Sachel Mok, Tomas Yeo, Davin Hong, Melanie J. Shears, Leila S. Ross, Kurt E. Ward, Satish K. Dhingra, Mariko Kanai, Jessica L. Bridgford, Abhai K. Tripathi, Godfree Mlambo, Anna Y. Burkhard, Megan R. Ansbro, Kate J. Fairhurst, Eva Gil-Iturbe, Heekuk Park, Felix D. Rozenberg, Jonathan Kim, Filippo Mancia, Rick M. Fairhurst, Matthias Quick, Anne-Catrin Uhlemann, Photini Sinnis, David A. Fidock
Science Advances 2023;9(45);eadi2364
Evolution and spread of Plasmodium falciparum mutations associated with resistance to sulfadoxine-pyrimethamine in central Africa: a cross-sectional study
Emilie Guémas, Romain Coppée, Sandie Ménard, Milena du Manoir, Sandrine Nsango, Dieudonné Makaba Mvumbi, Emmanuel Nakoune, Carole Else Eboumbou Moukoko, Marielle Karine Bouyou Akotet, Tatfeng Youtchou Mirabeau, Sylvie Manguin, Doudou Malekita Yobi, Jean Akiana, Lady Charlène Kouna, Denise Patricia Mawili Mboumba, Dominique Fatima Voumbo-Matoumona, Alliance-Laure Otam, Pierre-Alain Rubbo, Jean-Pierre Lombart, Elisabeth Kwanai, Olivia Cohen, Xavier Iriart, Lawrence Ayong, Jean Bernard Lekana-Douki, Frédéric Ariey, Antoine Berry
Lancet Microbe 2023;4(12);e983-e993
MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites
Chengqi Wang, Yibo Dong, Chang Li, Jenna Oberstaller, Min Zhang, Justin Gibbons, Camilla Valente Pires, Mianli Xiao, Lei Zhu, Rays H. Y. Jiang, Kami Kim, Jun Miao, Thomas D. Otto, Liwang Cui, John H. Adams & Xiaoming Liu
Genome Biology 2023;24(231)
Molecular surveillance of Plasmodium falciparum drug-resistance markers in Vietnam using multiplex amplicon sequencing (2000–2016)
Eduard Rovira-Vallbona, Johanna Helena Kattenberg, Nguyen Van Hong, Pieter Guetens, Hideo Imamura, Pieter Monsieurs, Driss Chiheb, Annette Erhart, Bui Quang Phuc, Nguyen Xuan Xa & Anna Rosanas-Urgell
Scientific Reports 2023;13;13948
A potent and durable malaria transmission-blocking vaccine designed from a single-component 60-copy Pfs230D1 nanoparticle
Nichole D. Salinas, Rui Ma, Thayne H. Dickey, Holly McAleese, Tarik Ouahes, Carole A. Long, Kazutoyo Miura, Lynn E. Lambert & Niraj H. Tolia
npj Vaccines 2023;8(124)
Genomic analysis of Plasmodium falciparum isolates across different altitudinal zones along the slope of Mount Cameroon
Tobias O. Apinjoh, Marcelus U. Ajonina, Deriba Abera, Hanesh F. Chi, Roland B. Tata, Regina N. Mugri, Lemu Golassa, Eric A. Achidi, Alfred Amambua-Ngwa
Frontiers in Malaria 2023;1
An optimized GATK4 pipeline for Plasmodium falciparum whole genome sequencing variant calling and analysis
Karamoko Niaré, Bryan Greenhouse & Jeffrey A. Bailey
Malaria Journal 2023;22(207)
Highly multiplexed ddPCR-amplicon sequencing reveals strong Plasmodium falciparum population structure and isolated populations amenable to local elimination efforts in Zanzibar
Aurel Holzschuh, Anita Lerch, Inna Gerlovina, Bakar S. Fakih, Abdul-wahid H. Al-mafazy, Erik J. Reaves, Abdullah Ali, Faiza Abbas, Mohamed Haji Ali, Mohamed Ali Ali, Manuel W. Hetzel, Joshua Yukich & Cristian Koepfli
Nat Commun 2023;14(3699)
Genome-wide genetic variation and molecular surveillance of drug resistance in Plasmodium falciparum isolates from asymptomatic individuals in Ouélessébougou, Mali
Leen N Vanheer, Almahamoudou Mahamar, Emilia Manko, Sidi M Niambele, Koualy Sanogo, Ahamadou Youssouf, Adama Dembele, Makonon Diallo, Seydina O Maguiraga, Jody Phelan, Ashley Osborne, Anton Spadar, Merel J Smit, Teun Bousema, Chris Drakeley, Taane G Clark, William Stone, Alassane Dicko, Susana Campino
Scientific Reports 2023;13(1);9522
coiaf: Directly estimating complexity of infection with allele frequencies
Aris Paschalidis, Oliver J. Watson, Ozkan Aydemir, Robert Verity , Jeffrey A. Bailey
PLoS Comput Biol 2023;19(6);e101024
Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique
Clemente da Silva, Simone Boene, Debayan Datta, Eduard Rovira-Vallbona, Andrés Aranda-Díaz, Pau Cisteró, Nicholas Hathaway, Sofonias Tessema, Arlindo Chidimatembue, Glória Matambisso, Abel Nhama, Eusebio Macete, Arnau Pujol, Lidia Nhamussua, Beatriz Galatas, Caterina Guinovart, Sónia Enosse, Eva De Carvalho, Eric Rogier, Mateusz M. Plucinski, James Colborn, Rose Zulliger, Abuchahama Saifodine, Pedro L. Alonso, Baltazar Candrinho, Bryan Greenhouse, Pedro Aide, Francisco Saute & Alfredo Mayor
Communications Biology 2023;6(619)
Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique
Clemente da Silva, Simone Boene, Debayan Datta, Eduard Rovira-Vallbona, Andrés Aranda-Díaz, Pau Cisteró, Nicholas Hathaway, Sofonias Tessema, Arlindo Chidimatembue, Glória Matambisso, Abel Nhama, Eusebio Macete, Arnau Pujol, Lidia Nhamussua, Beatriz Galatas, Caterina Guinovart, Sónia Enosse, Eva De Carvalho, Eric Rogier, Mateusz M. Plucinski, James Colborn, Rose Zulliger, Abuchahama Saifodine, Pedro L. Alonso, Baltazar Candrinho, Bryan Greenhouse, Pedro Aide, Francisco Saute & Alfredo Mayor
Nature Communications Biology 2023;6;619
Performance of SNP barcodes to determine genetic diversity and population structure of Plasmodium falciparum in Africa
Dionne C Argyropoulos, Mun Hua Tan, Courage Adobor, Benedicta Mensah, Frédéric Labbé, Kathryn E Tiedje, Kwadwo A Koram, Anita Ghansah, Karen P Day
Frontiers in Genetics 2023;13
Genomic analysis of Indian isolates of Plasmodium falciparum: Implications for drug resistance and virulence factors
Deepak Choubey, Bhagyashree Deshmukh, Anjani Gopal Rao, Abhishek Kanyal, Amiya Kumar Hati, Somenath Roy, Krishanpal Karmodiya
Int J Parasitol Drugs Drug Resist 2023;22;52–60
MinSNPs: an R package for derivation of resolution-optimised SNP sets from microbial genomic data
Hoon KS, Holt DC, Auburn S, Shaw P, Giffard PM
PeerJ 2023;11;e15339
Genomic variation during culture adaptation of genetically complex Plasmodium falciparum clinical isolates
Claessens A, Stewart LB, Drury E, Ahouidi AD, Amambua-Ngwa A, Diakite M, Kwiatkowski DP, Awandare GA, Conway DJ.
Microbial Genomics 2023;9(5)
Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1
Alfred Amambua-Ngwa, Katrina A. Button-Simons, Xue Li , Sudhir Kumar , et al
Nature Microbiology 2023;8;1213–1226
Population dynamics and drug resistance mutations in Plasmodium falciparum on the Bijagós Archipelago, Guinea-Bissau
Sophie Moss, Emilia Mańko, Hristina Vasileva, Eunice Teixeira Da Silva, Adriana Goncalves, Ashley Osborne, Jody Phelan, Amabelia Rodrigues, Paulo Djata, Umberto D'Alessandro, David Mabey, Sanjeev Krishna, Anna Last, Taane G Clark, Susana Campino
Scientific Reports 2023;13(1);6311
Characterization of a novel Plasmodium falciparum merozoite surface antigen and potential vaccine target
Karamoko Niaré, Timothy Chege, Micha Rosenkranz, Kennedy Mwai, Zoe Saßmannshausen, Dennis Odera, Lydia Nyamako, James Tuju, Tiono Alfred, John N Waitumbi, Bernhards Ogutu, Sodiomon B Sirima, Gordon Awandare, Bourema Kouriba, Julian C Rayner, Faith H A Osier
Frontiers Immunology 2023;14;1156806
Population Genomic Evidence of Adaptive Response during the Invasion History of Plasmodium falciparum in the Americas
Margaux J M Lefebvre, Josquin Daron, Eric Legrand, Michael C Fontaine, Virginie Rougeron, Franck Prugnolle
Mol Biol Evol 2023;40(5);msad082
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation
Selina Bopp, Charisse Flerida A. Pasaje, Robert L. Summers, Pamela Magistrado-Coxen, Kyra A. Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S. Nasamu, Allison R. Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M. Early, Amanda K. Lukens, Danny Milner, Jeremy Furtado, Francisco-Javier Gamo, Elizabeth A. Winzeler, Sarah K. Volkman, Maëlle Duffey, Benoît Laleu, David A. Fidock, Susan Wyllie, Jacquin C. Niles, Dyann F. Wirth
Nat Commun 2023;14(1455)
Genetic diversity and natural selection of rif gene (PF3D7_1254800) in the Plasmodium falciparum global populations
Shao-Jie Xu, Hai-Mo Shen, Yan-Bing Cui, Shen-Bo Chen, Bin Xu, Jun-Hu Chen
Mol Biochem Parasitol 2023;254;111558
Limited genetic variations of the Rh5-CyRPA-Ripr invasion complex in Plasmodium falciparum parasite population in selected malaria-endemic regions, Kenya
Harrison Waweru, Bernard N. Kanoi, Josiah O. Kuja, Mary Maranga, James Kongere, Michael Maina, Johnson Kinyua and Jesse Gitaka
Frontiers in Tropical Disease 2023;4;1102265
Malaria Molecular Surveillance in the Peruvian Amazon with a Novel Highly Multiplexed Plasmodium falciparum AmpliSeq Assay
Johanna Helena Kattenberg, Carlos Fernandez-Miñope, Norbert J. van Dijk, Lidia Llacsahuanga Allcca, Pieter Guetens, Hugo O. Valdivia, Jean-Pierre Van geertruyden, Eduard Rovira-Vallbona, Pieter Monsieurs, Christopher Delgado-Ratto, Dionicia Gamboa, Anna Rosanas-Urgell
Microbiology Spectrum 2023;11;e00960-22
Nosocomial Malaria Transmissions Resolved by Genomic Analyses—A Retrospective Case Report Study in France: 2007–2021
Romain Coppée, Véronique Sarrasin, Rizwana Zaffaroulah, Azza Bouzayene, Marc Thellier, Harold Noël, Jérôme Clain, Sandrine Houzé, the Investigation Study Group
Clinical Infectious Diseases 2023;76(4);631–639
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230
Danton Ivanochko, Amanda Fabra-García, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Jocelyn Newton, Anthony Semesi, Marloes de Bruijni, Judith Bolscher, Jordache Ramjith, Marta Szabat, Stefanie Vogt, Lucas Kraft, Sherie Duncan, Shwu-Maan Lee, Moses R. Kamya, Margaret E. Feeney, Prasanna Jagannathan, Bryan Greenhouse, Robert W. Sauerwein, C. Richter King, Randall S. MacGill, Teun Bousema, Matthijs M. Jore, Jean-Philippe Julien
Immunity 2023;56(2);420–432
Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum
Kucharski M, Wirjanata G, Nayak S, Boentoro J, Dziekan JM, Assisi C, van der Pluijm RW, Miotto O, Mok S, Dondorp AM, Bozdech Z.
PLOS Pathogens 2023;19(1);e1011118
Role of Pfs47 in the dispersal of ancestral Plasmodium falciparum malaria through adaptation to different anopheline vectors
Molina-Cruz A, Canepa GE, Dwivedi A, Liu W, Raytselis N, Antonio-Nkondjio C, Hahn BH, Silva JC, Barillas-Mury C.
PNAS 2023;120(5);e2213626120
Genetic Epidemiology Use Cases for Malaria Control Programmes: A Methodology
Olivo Miotto, Principal Investigator, GenRe-Mekong Project
Genetic Epidemiology Use Cases for Malaria Control Programmes: A Methodology 2023
Pf7: An open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples
MalariaGEN et. al
Wellcome Open Research 2023;8;22
Unravelling var complexity: Relationship between DBLα types and var genes in Plasmodium falciparum
Mun Hua Tan, Heejung Shim, Yao-ban Chan, Karen P. Day
Front Parasitol 2023;1;1006341
Drug Resistant Prediction Based on Plasmodium falciparum DNA-Barcoding using Bidirectional Long Short Term Memory Method
Lailil Muflikhah, Nashi Widodo, Novanto Yudistira, Achmad Ridok
International Journal of Advanced Computer Science and Applications (IJACSA) 2023;14(7)
Drug resistance and population structure of Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon
Villena FE, Sanchez JF, Nolasco O, Braga G, Ricopa L, Barazorda K, Salas CJ, Lucas C, Lizewski SE, Joya CA, Gamboa D, Delgado-Ratto C, Valdivia HO
Scientific Reports 2022;12(1);16474
Phenotypic characterization of Ghanaian P. falciparum clinical isolates reveals a homogenous parasite population
Laty G. Thiam, Prince B. Nyarko, Felix Ansah, Makhtar Niang, Gordon A. Awandare, Yaw Aniweh
Frontiers Immunology 2022;13;1009252
Design and implementation of multiplexed amplicon sequencing panels to serve genomic epidemiology of infectious disease: A malaria case study
LaVerriere E, Schwabl P, Carrasquilla M, Taylor AR, Johnson ZM, Shieh M, Panchal R, Straub TJ, Kuzma R, Watson S, Buckee CO, Andrade CM, Portugal S, Crompton PD, Traore B, Rayner JC, Corredor V, James K, Cox H, Early AM, MacInnis BL, Neafsey DE.
Molecular Ecology Resources 2022;22;2285
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