Host-parasite open data resources

The host-parasite data resource includes a publication which tests for association between human and Plasmodium falciparum genetic variants.

Resource 32: We used DNA from over 4,000 children ascertained with severe malaria in the period 1995-2009 to test for association between human and P. falciparum genetic variants.  All individuals were from Banjul, The Gambia, and from Kilifi County, Kenya, and were previously analysed for human genotypes (see doi:10.1038/s41467-019-13480-z and  https://www.malariagen.net/resource/25). For this study, we generated P. falciparum genome sequence reads using the Illumina X Ten platform and used this to identify and call parasite genetic variation.  We then tested for association between human and parasite variants using a logistic regression approach implemented in the software HPTEST (https://www.well.ox.ac.uk/~gav/hptest).